LSD
Maclay Rehabilitation Center
LSD

Chemist Albert Hofmann, working at the Sandoz Corporation pharmaceutical laboratory
in Switzerland, first synthesized LSD in 1938. He was conducting research on possible
medical applications of various lysergic acid compounds derived from ergot, a fungus
that develops on rye grass. Searching for compounds with therapeutic value, Hofmann
created more than two dozen ergot-derived synthetic molecules.

LSD is sold on the street in tablets, capsules, and occasionally in liquid form. It is an
odorless and colorless substance with a slightly bitter taste that is usually ingested
orally. It is often added to absorbent paper, such as blotter paper, and divided into small
decorated squares, with each square representing one dose.

Short-Term Effects

The short-term effects of LSD are unpredictable. They depend on the amount of the
drug taken; the user's personality, mood, and expectations; and the surroundings in
which the drug is used. Usually, the user feels the first effects of the drug within 30 to
90 minutes of ingestion. These experiences last for extended periods of time and
typically begin to clear after about 12 hours. The physical effects include dilated pupils,
higher body temperature, increased heart rate and blood pressure, sweating, loss of
appetite, sleeplessness, dry mouth, and tremors. Sensations may seem to "cross over"
for the user, giving the feeling of hearing colors and seeing sounds. If taken in a large
enough dose, the drug produces delusions and visual hallucinations.

Long-Term Effects

LSD users often have flashbacks, during which certain aspects of their LSD experience
recur even though they have stopped taking the drug. In addition, LSD users may
develop long-lasting psychoses, such as schizophrenia or severe depression. LSD is
not considered an addictive drug - that is, it does not produce compulsive drug-seeking
behavior as cocaine, heroin, and methamphetamine do. However, LSD users may
develop tolerance to the drug, meaning that they must consume progressively larger
doses of the drug in order to continue to experience the hallucinogenic effects that they
seek.

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