OxyCotin
Maclay Rehabilitation Center
OxyCotin

OxyContin® is a prescription painkiller used for moderate to high pain relief associated
with injuries, bursitis, dislocations, fractures, neuralgia, arthritis, lower back pain, and
pain associated with cancer.OxyContin® contains oxycodone, the medication's active
ingredient, in a timed-release tablet. Oxycodone products have been illicitly abused for
the past 30 years.

Oxycodone is a Schedule II narcotic analgesic and is widely used in clinical medicine.
It is marketed either alone as controlled release (OxyContin®) and immediate release
formulations (OxyIR®, OxyFast®), or in combination with other nonnarcotic analgesics
such as aspirin (Percodan®) or acetaminophen (Percocet®). The introduction in 1996
of OxyContin®, commonly known on the street as OC, OX, Oxy, Oxycotton, Hillbilly
heroin, and kicker, led to a marked escalation of its abuse as reported by drug abuse
treatment centers, law enforcement personnel, and health care professionals.
Although the diversion and abuse of OxyContin® appeared initially in the eastern US, it
has now spread to the western US including Alaska and Hawaii. Oxycodone-related
adverse health effects increased markedly in recent years. In 2004, Food and Drug
Administration (FDA) approved for marketing generic forms of controlled release
oxycodone products.

Short-Term Effects

Pharmacological effects include analgesia, sedation, euphoria, feelings of relaxation,
respiratory depression, constipation, papillary constriction, and cough suppression. A
10 mg dose of orally-administered oxycodone is equivalent to a 10 mg dose of
subcutaneously administered morphine as an analgesic in a normal population.
Oxycodone’s behavioral effects can last up to 5 hours. The drug is most often
administered orally. The controlled-release product, OxyContin®, has a longer duration
of action (8-12 hours).

The most serious risk associated with opioids, including OxyContin®, is respiratory
depression. Common opioid side effects are constipation, nausea, sedation,
dizziness, vomiting, headache, dry mouth, sweating, and weakness. Taking a large
single dose of an opioid could cause severe respiratory depression that can lead to
death.

Long-Term Effects

As with most opiates, oxycodone abuse may lead to dependence and tolerance. Acute
overdose of oxycodone can produce severe respiratory depression, skeletal muscle
flaccidity, cold and clammy skin, reduction in blood pressure and heart rate, coma,
respiratory arrest, and death.

Chronic use of opioids can result in tolerance for the drugs, which means that users
must take higher doses to achieve the same initial effects. Long-term use also can
lead to physical dependence and addiction -- the body adapts to the presence of the
drug, and withdrawal symptoms occur if use is reduced or stopped. Properly managed
medical use of pain relievers is safe and rarely causes clinical addiction, defined as
compulsive, often uncontrollable use of drugs. Taken exactly as prescribed, opioids
can be used to manage pain effectively

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